Drug-Drug Interaction (DDI) Alert

Clinical enables medical professionals to write prescriptions for drugs, durable medical equipment (DME), or supplies that can be printed for the patient or sent electronically to the pharmacy. With each new medication prescribed, Clinical automatically checks for, and alerts you to, the potential for significant drug-drug interactions or allergic reactions.

A Drug-Drug Interaction alert message appears when a prescribed drug has the potential to cause significant interactions with other drugs in the patient's Active Medications list. There are three Drug-Drug Alert severity levels:

• ​Major Drug Interaction: The effects may result in death, hospitalization, permanent injury, or therapeutic failure.
• Moderate Drug Interaction: Medical intervention is needed to treat effects; effects do not meet criteria for Major.
• Minor Drug Interaction: The effects would be considered tolerable in most cases - no need for medical intervention.

Based on your Drug-Drug Alert notification settings, you have the following choices when an alert appears: 

• Select an Override Reason and proceed with the prescription
• Override the alert and proceed with the prescription​ without selecting an override reason
• Cancel the prescription and choose an alternate drug

Create Prescription Enter the first 2–3 letters of the patient's name or date of birth (mm/dd/yyyy) in the top navigation bar search box. Click to select the patient from the auto-populated results. The patient's Facesheet page opens. Click Medications. The Active Medications page opens. Click + Prescription. The Prescribe Medication page opens. Prescribe the medication. The Interaction Warning pop-up window opens.

Review Drug-Drug Interaction Review Interaction Details: Existing Prescription: The patient's active medication that interacts with the medication being prescribed. Severity Level: Displays the interaction severity level (e.g., mild, moderate). Interaction Type: Displays the interaction type (e.g., drug-drug) DDI Severity Details: Click the down arrow to display information about the drug interaction. Override Reason: If applicable, click to select the reason(s) to override the alert to continue prescribing the selected medication. Note: Based on the practice's Drug Interaction notification settings, an override reason may not be required to continue prescribing. Click Apply Override Reason. Click Submit to continue prescribing the medication. To clear the prescription fields and prescribe a new medication, click Cancel Rx.